On June 11, 2025, Carlos Santana celebrated the 15th anniversary of his Major League Baseball debut by hitting his sixth career grand slam. His powerful hit helped the Cleveland Guardians secure an 11-2 victory over the Cincinnati Reds in the final game of the Ohio Cup, ending the Reds' five-game winning streak and preventing manager Terry Francona from sweeping his former team this season. Following this game, the Guardians faced the Seattle Mariners in a series where Emerson Hancock pitched seven scoreless innings, and J.P. Crawford contributed a grand slam. The Mariners completed a sweep of the Guardians with a 6-0 win on June 15, 2025, improving their record to .500.